Pharmacologic Preconditioning: Translating the Promise

pharmacogenetics, the promise of translating personalized medicine into clinical pediatrics

Pharmacologic vitreolysis--premise and promise of the first decade.

Pharmacologic Vitreolysis— Premise and Promise of the First Decade The term pharmacologic vitreolysis first appeared in the world’s literature one decade ago in the pages of the journal Retina.1 The coining of this term formalized a new field and was predicated on a premise and a promise. The premise was that we now understood enough about the molecular organization, structure, and physiology o...

effects of pharmacologic preconditioning with natural honey on the left ventricle perfusion pressure in isolated heart

Translating genomic research into clinical practice: promise and pitfalls.

Breast cancer is a heterogeneous disease associated with variable clinical outcomes despite standard local therapy for the primary tumor and systemic adjuvant therapy to prevent distant recurrence. Management decisions are typically made using classical prognostic and predictive clinicopathologic factors, and more recently gene expression profiling assays are commonly used in practice. Recent a...

Ganetespib and HSP90: translating preclinical hypotheses into clinical promise.

As with many physiologic processes that become subverted during tumorigenesis, the chaperoning activity of heat shock protein 90 (HSP90) is often exploited by cancer cells to confer aberrant proliferative, survival, and/or metastatic potential. Functional inhibition of HSP90 results in the degradation of its client proteins, in turn providing a means to concomitantly disrupt multiple oncogenic ...